Cell and Development Biology

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Cell and Developmental Biology at the Ludwig-Maximilians-University München

Research in the Department of Cell and Developmental Biology focuses on fundamental questions in the Life Sciences such as cell death and proliferation, stem cells, organellar dynamics, cation homeostasis and the control of gene expression.

To address these questions, we employ bottom-up as well as top-down approaches and state of the art technologies. As models, we are currently using the yeast Saccharomyces cerevisiae, the cnidarians Hydra vulgaris, the nematode Caenorhabditis elegans, the vertebrate Danio rerio as well as mammalian cells.




New Publication Eric Lambie:

The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex

Hollopeter, G, Lange, JJ, Zhang, Y, Vu, TN, Gu, M, Ailion, M, Lambie, EJ, Slaughter, BD, Unruh, JR, Florens, L, Jorgensen, EM, published October 10, 2014, eLife 2014; 10.7554/eLife.03648


The prestigious Emmy-Noether fellowship was awarded to Esther Zanin to establish an independent research group at the Department of Cell- and Developmental Biology. Aim of the research group is to elucidate the mechanisms that control cytokinesis in animal cells (http://www.cellbiology.bio.lmu.de/people/principal_investigators/esther_zanin/index.html).



New publications:

Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan.

Regmi, SG, Rolland SG, Conradt B, Aging (Albany NY). 2014 Feb; 6(2):118-30


A Complex Regulatory Network Coordinating Cell Cycles During C. elegans Development Is Revealed by a Genome-Wide RNAi Screen.

Roy, SH, Tobin DV, Memar N., Beltz, E., Holmen, J. Clayton, JE, Chiu, DJ, Young, LD, Green, TH, Lubin, I, Liu, Y, Conradt, B, Saito, RM. G3 (Bethesda). 2014 Feb 28;4(5):795-804. doi: 10.1534/g3.114.010546.



Presentations at international meeting

Berlin C. elegans Meeting 2014, May 15-17, Max Delbrück Center (MDC), Berlin


Esther Zanin
“TPXL-1 mediates aster-based clearing of contractile ring proteins from the cell poles during cytokinesis.”

Tamara Mikeldaze-Dvali

“C. elegans CED-3 caspase is required for centrosomal asymmetry in a cell lineage that generates an apoptotic death.“



New funding from the Natural Sciences and Engineering Research Council of Canada (NSERC) for Ryan Sherrard

Postgraduate Scholarship-Doctoral




Presentations at international meeting

Keystone Symposia on Molecular and Cellular Biology; “The Chemistry and Biology of Cell Death”, Santa Fe, New Mexico, U.S.A., February 18-23, 2014


Barbara Conradt

“C. elegans CED-3 Caspase Regulates Centrosome Asymmetry in an Apoptotic Death.”