Cell and Development Biology

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Publications Böttger

Department Biologie II, Ludwig-Maximilians-University, Munich, Germany
since 1998









  • Schofield, C.J., Webby, C.J., Böttger, A., Wolf, A. (2008). Assay for monitoring activity of Jmjd6. International Application No.: PCT/GB2009/001270; Pub. No.: WO/2009/141609 Priority Data: 0809262.9, 21.05.2008, GB.







  • Böttger, A. and David, C.N. (2002). Evolution of Cell Death:  Caspase mediated mechanisms in early Metazoans; non-Caspase Mechanisms in single-celled Eukaryotes 'Genetics of apoptosis', BIOS scientific publishers, ISBN: 1859960642, Stefan Grimm (Ed.).

  • Herold, M., Cikala, M., David, C.N. and Böttger, A. (2002). Cloning and characterisation of PKB and PRK from Hydra and the evolution of protein kinases. Dev., Genes and Evol., 212: 513-519.

  • Böttger, A., Alexandrova, O., Cikala, M., Schade, M., Herold, M., and David, C.N. (2002). GFP expression in Hydra: Lessons from the particle gun. Dev. Genes and Evol., 212: 302-305.


  • Cikala, M., Wilm, B., Hobmayer, E., Böttger, A., and David, C.N. (1999). Identification of caspases and apoptosis in the simple metazoan hydra. Curr Biol 9, 959-62.

    Department of Biochemistry, University Dundee, Scotland, U.K., 
  • Böttger, V., Böttger, A., Garcia-Echeverria, C., Ramos, Y.F., van der Eb, A.J., Jochemsen, A.G., and Lane, D.P. (1999). Comparative study of the p53-mdm2 and p53-MDMX interfaces. Oncogene 18, 189-99.

  • Böttger, A., Böttger, V., Garcia-Echeverria, C., Chene, P., Hochkeppel, H.K., Sampson, W., Ang, K., Howard, S.F., Picksley, S.M., and Lane, D.P. (1997). Molecular characterization of the hdm2-p53 interaction. J Mol Biol 269, 744-56.

  • Böttger, A., Böttger, V., Sparks, A., Liu, W.L., Howard, S.F., and Lane, D.P. (1997). Design of a synthetic Mdm2-binding mini-protein that activates the p53 response in vivo. Curr Biol 7, 860-9.

  • Böttger, V., Böttger, A., Howard, S.F., Picksley, S.M., Chene, P., Garcia-Echeverria, C., Hochkeppel, H.K., and Lane, D.P. (1996). Identification of novel mdm2 binding peptides by phage display. Oncogene 13, 2141-7.

  • Böttger, A. and Spruce, B.A. (1995). Proenkephalin is a nuclear protein responsive to growth arrest and differentiation signals. J Cell Biol 130, 1251-62.

  • Böttger, V., Böttger, A., Lane, E.B., and Spruce, B.A. (1995). Comprehensive epitope analysis of monoclonal anti-proenkephalin antibodies using phage display libraries and synthetic peptides: revelation of antibody fine specificities caused by somatic mutations in the variable region genes. J Mol Biol 247, 932-46.

  • Böttger, A, Hannah, M., Lowry, P.J. and Spruce, B.A. (1995). Nuclear Localisation of proenkephalin in fibroblast and myoblast cell lines. Analgesia1:4-6, 318-22.

  • Spruce, B.A., Prescott, A., Böttger, A., and Dewar, D.A. (1994). Agents for inducing apoptosis and application of said agents in therapy. International Patent No. PCT/GB9S/02037. Priority Date: 30th August 1994, granted 1997.

    Institute of Drug Research, former Academy of Sciences, GDR, Berlin
    1981 -1992

  • Melzig, M. F., Pieper, S., Siems, W.E., Heder, G., Böttger, A., Liberra, K., and Lindequist, U. (1996). Screening of selected basidiomycetes for inhibitory activity on neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE). Pharmazie 51, 501-3.

  • Heder, G., Böttger, A., Siems, W.E., Rottmann, M., and Kertscher, U. (1994). The enzymatic degradation of bradykinin in semen of various species. Andrologia 26, 295-301.

  • Siems, W.E., Heder, G., Böttger, A., Winkler, A., Zipper, J., and Mueller-Esterl, W. (1994). Influence of bradykinin and peptidase inhibitors on the motility of mammalian spermatozoa. Can. J. Pharmacol. 72, 203.

  • Böttger, A., Kertscher, U., Steinmann, C., Baeger, U., Siems, W.E., and Heder, G. (1993). Degradation of bradykinin in semen of ram and boar. Biochem Pharmacol 45, 1983-8.

  • Siems, W.E., Hilse, H., Heder, G., and Böttger, A. (1992). Influences of bradykinin on the motility of spermatozoa. Arch.Pharmacol. 346, 16.

  • Heder, G., Böttger, A., Siems, W.E., Halatsch, W.R., and Steinmann, C. (1988). The determination of neutral metalloendopeptidase (enkephalinase A) in biological material. Pharmazie 43: 637-9.