Publications Böttger
Department Biologie II, Ludwig-Maximilians-University, Munich, Germany
since 1998
2015
- Böttger A., Islam MS. Chowdhury R., Schofield CJ., Wolf A. (2015) The oxygenase Jmjd6--a case study in conflicting assignments. Biochem J. 2015 Jun 1;468(2):191-202. doi: 10.1042/BJ20150278.
2014
- Heim, A., Grimm, C., Müller, U., Häußler, S., Mackeen, Mukram M. , Merl, J., Hauck, S.M., Kessler, B.M., Schofield, C.J., Wolf, A., Böttger, A. (2014). Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine–serine-rich (RS) domains of SR- and SR-like proteins. Nucleic Acid Research 42(12):7833-50.
- Takaku, Y., Hwang, J.S., Wolf, A., Boettger, A., Shimizu, H., David, C.N. and Gojobori,T. (2014). Innexin gap junctions in nerve cells coordinate spontaneous contractile behavior in Hydra polyps. Scientific Reports 4 : 3573 | DOI: 10.1038/srep03573
2013
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Tischer, S., Reineck, .M, Söding, J., Münder, S., Böttger, A. (2013). Eph receptors and ephrin class B ligands are expressed at tissue boundaries in Hydra vulgaris, Int J Dev Biol. 2013;57(9-10):759-65. doi: 10.1387/ijdb.130158ab.
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Münder, S., Tischer, S., Grundhuber, M., Buchels, N., Bruckmeier, N., Eckert, S., Seefeldt, C.A., Prexl, A., Kasbauer, T., Böttger, A. (2013). Notch-signalling is required for head regeneration and tentacle patterning in Hydra. Dev Biol. 2013 Nov 1;383(1):146-57. doi: 10.1016/j.ydbio.2013.08.022. Epub 2013 Sep 6.
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Wolf, A., Mantri, M., Heim, A., Muller, U., Fichter, E., Mackeen, M.M., Schermelleh, L., Dadie, G., Leonhardt, H., Venien-Bryan, C., Kessler, B.M., Schofield, C.J., Böttger, A. (2013). The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization. The Biochemical Journal 453, 357-370.
2012
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Böttger, A., Doxey, A.C., Hess, M.W., Pfaller, K., Salvenmoser, W., Deutzmann, R., Geissner, A., Pauly, B., Altstätter, J., Münder, S., Heim, A., Gabius, H.J., McConkey, B.J., David, C.N. (2012). Horizontal Gene Transfer Contributed to the Evolution of Extracellular Surface Structures: The Freshwater Polyp Hydra Is Covered by a Complex Fibrous Cuticle Containing Glycosaminoglycans and Proteins of the PPOD and SWT (Sweet Tooth) Families. PLoS One 7 (12), e52278.
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Böttger, A. and Hassel, M. (2012). Hydra, a model system to trace the emergence of boundaries in developing eumetazoans. Int J. Dev. Biol 56 (6-8); 583-591.
2011
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Mantri, M., Webby, C.J., Loik, N.D., Hamed, R.B., Nielsen, M.L., McDonough, M.A., McCullagh, J.S.O., Böttger, A., Schofield, C.J.*, and Wolf, A. (2011). Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6. Med. Chem. Commun., 2012,3, 80-85.
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Prexl, A., Münder, S., Loy, B., Kremmer, E., Tischer, S, and Böttger, A. (2011). The putative Notch Ligand HyJagged is a transmembrane protein present in all cell types of adult hydra and upregulated at the boundary between bud and parent. BMC Cell Biology 12 (38).
2010
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Hahn, P., Wegener, I., Burrells, A., Böse, J., Wolf, A., Erck, C., Butler, D., Schofield, C.J., Böttger, A., Lengeling, A. (2010). Analysis of jmjd6 cellular localization and testing for its involvement in histone demethylation. PLoS One, 5(10).
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Münder, S., Käsbauer, T., Prexl, A., Aufschnaiter, R., Zhang, X., Towb, P., and Böttger, A. (2010). Notch signalling defines critical boundary during budding in Hydra. Developmental Biology 2010, 344(1):331-45.
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Lasi, M., Pauly, B., Schmidt, N., Cikala, M., Stiening, B., Käsbauer, T., Zenner, G., Popp, T., Knapp, R.H., Wagner, A., Huber, A.H., Grunert, M., Söding, J., David, C.N., Böttger, A. (2010). The molecular cell death machinery in the simple cnidarian Hydra includes an expanded caspase family and pro- and antiapoptotic Bcl-2 proteins. Cell Research 20: 812-825.
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Chapman, J.A., Kikness, E.F., Simiakov,O....Böttger, A....Rokshar, D.S., Steele, R.E. (2010). The Dynamic Genome of Hydra. Nature 464 (7288):592-6.
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Lasi, M., David, C.N., Böttger, A. (2010) Apoptosis in Pre-Bilaterians: Hydra as a model. Apoptosis 15 (3): 269.
2009
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Webby, C.J., Wolf, A., Gromak, N., Dreger, M., Kramer, H., Kessler, B., Nielsen, M.L., Schmitz, C., Butler, D.S., Yates, J.R. 3rd, Delahunty, C.M., Hahn, P., Lengeling, A., Mann, M., Proudfoot, N.J., Schofield, C.J., Böttger, A. (2009). Jmjd6 catalyses Lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science 325: 90-93.
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Böttger, V. and Böttger, A. (2009) Epitope mapping using phage display Peptide libraries. Methods in Molecular Biology, 524:181-201.
2008
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Schofield, C.J., Webby, C.J., Böttger, A., Wolf, A. (2008). Assay for monitoring activity of Jmjd6. International Application No.: PCT/GB2009/001270; Pub. No.: WO/2009/141609 Priority Data: 0809262.9, 21.05.2008, GB.
2007
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Pauly, B., Lasi, M., Mackintosh, C., Morrice, N., Imhof, A., Regula, J., Rudd, S., David, C.N., Böttger, A. (2007). Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signalling. BMC Cell Biol. 8(1):31.
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Wolf, A., Schmitz, C., and Böttger, A. (2007). Changing story of the receptor for phosphatidylserine-dependent clearance of apoptotic cells. EMBO Rep 8, 465-9.
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Böttger, A. and Alexandrova, O. (2007). Programmed Cell Death in Hydra. Review, Seminars in Cancer Biology 17, 134-146.
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Käsbauer, T., Towb, P., Alexandrova, O., David, C.N., Dall’Armi, E., Staudigl, A., Stiening, B., and Böttger, A. (2007). The Notch signalling pathway in the cnidarian Hydra. Developmental Biology 303(1):376-90.
2006
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Böttger, A., Strasser, D., Alexandrova, O., Levin, A., Fischer, S., Lasi, M., Rudd1, S., and David, C.N. (2006). Genetic screen for signal peptides in Hydra reveals novel secreted proteins and evidence for non-classical protein secretion. Eur.J Cell Biol, 85 (2006) 1107-1117.
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Müller-Taubenberger, A., Vos, M.J., Böttger, A., Lasi, M., Fischer, M., Lai, F.P.L., Rottner, K. (2006). Monomeric red fluorescent protein variants used for imaging studies in different species. Eur.J Cell Biol, 85 (2006) 1119-1129.
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Seipp, S., Wittig, K., Böttger, A., Stiening, B., and Leitz, T. (2006). Metamorphosis of Hydractinia echinata (Cnidaria) is caspase-dependent. Int. J. Dev. Biol, 50: 63-70.
2005
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Alexandrova, O., Schade, M., Böttger, A., and David, C.N. (2005). Oogenesis in hydra: nurse cells transfer cytoplasm directly to the growing oocyte. Developmental Biology, 281(1): 91-101.
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David, C.N., Schmidt, N., Schade, M., Pauly, B., Alexandrova, O., and Böttger, A. (2005). Hydra and the evolution of apoptosis. Integr. Comp. Biol.: 45: 631-638.
2004
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Alexopoulus, H., Böttger, A., Fischer, S., Levin, A., Wolf, A., Fujisawa, T., Hayakawa, S., Gojobori, T., Davis, J.A., David, C.N., and Bacon, J.P. (2004). Evolution of gap junctions: The missing link., (Current Biology,14 (20): R879-80).
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Cikala, M., Alexandrova, O., David, C.N., Pröschel, M., Stiening, S., Cramer, P., and Böttger, A. (2004). The phosphatidylserine receptor (PSR) from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity (BMC CellBiology 5:26).
2003
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Pauly, B., Stiening, B., Schade, M., Zoubek, R., David, C.N., and Böttger, A. (2003). Molecular cloning and cellular distribution of two 14-3-3 isoforms from Hydra : 14-3-3 proteins respond to starvation and bind to phosphorylated targets. Exp.Cell Res., 285:15-26.
2002
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Böttger, A. and David, C.N. (2002). Evolution of Cell Death: Caspase mediated mechanisms in early Metazoans; non-Caspase Mechanisms in single-celled Eukaryotes 'Genetics of apoptosis', BIOS scientific publishers, ISBN: 1859960642, Stefan Grimm (Ed.).
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Herold, M., Cikala, M., David, C.N. and Böttger, A. (2002). Cloning and characterisation of PKB and PRK from Hydra and the evolution of protein kinases. Dev., Genes and Evol., 212: 513-519.
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Böttger, A., Alexandrova, O., Cikala, M., Schade, M., Herold, M., and David, C.N. (2002). GFP expression in Hydra: Lessons from the particle gun. Dev. Genes and Evol., 212: 302-305.
1999
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Cikala, M., Wilm, B., Hobmayer, E., Böttger, A., and David, C.N. (1999). Identification of caspases and apoptosis in the simple metazoan hydra. Curr Biol 9, 959-62.
Department of Biochemistry, University Dundee, Scotland, U.K.,
1992-1998 -
Böttger, V., Böttger, A., Garcia-Echeverria, C., Ramos, Y.F., van der Eb, A.J., Jochemsen, A.G., and Lane, D.P. (1999). Comparative study of the p53-mdm2 and p53-MDMX interfaces. Oncogene 18, 189-99.
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Böttger, A., Böttger, V., Garcia-Echeverria, C., Chene, P., Hochkeppel, H.K., Sampson, W., Ang, K., Howard, S.F., Picksley, S.M., and Lane, D.P. (1997). Molecular characterization of the hdm2-p53 interaction. J Mol Biol 269, 744-56.
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Böttger, A., Böttger, V., Sparks, A., Liu, W.L., Howard, S.F., and Lane, D.P. (1997). Design of a synthetic Mdm2-binding mini-protein that activates the p53 response in vivo. Curr Biol 7, 860-9.
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Böttger, V., Böttger, A., Howard, S.F., Picksley, S.M., Chene, P., Garcia-Echeverria, C., Hochkeppel, H.K., and Lane, D.P. (1996). Identification of novel mdm2 binding peptides by phage display. Oncogene 13, 2141-7.
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Böttger, A. and Spruce, B.A. (1995). Proenkephalin is a nuclear protein responsive to growth arrest and differentiation signals. J Cell Biol 130, 1251-62.
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Böttger, V., Böttger, A., Lane, E.B., and Spruce, B.A. (1995). Comprehensive epitope analysis of monoclonal anti-proenkephalin antibodies using phage display libraries and synthetic peptides: revelation of antibody fine specificities caused by somatic mutations in the variable region genes. J Mol Biol 247, 932-46.
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Böttger, A, Hannah, M., Lowry, P.J. and Spruce, B.A. (1995). Nuclear Localisation of proenkephalin in fibroblast and myoblast cell lines. Analgesia1:4-6, 318-22.
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Spruce, B.A., Prescott, A., Böttger, A., and Dewar, D.A. (1994). Agents for inducing apoptosis and application of said agents in therapy. International Patent No. PCT/GB9S/02037. Priority Date: 30th August 1994, granted 1997.
Institute of Drug Research, former Academy of Sciences, GDR, Berlin
1981 -1992 -
Melzig, M. F., Pieper, S., Siems, W.E., Heder, G., Böttger, A., Liberra, K., and Lindequist, U. (1996). Screening of selected basidiomycetes for inhibitory activity on neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE). Pharmazie 51, 501-3.
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Heder, G., Böttger, A., Siems, W.E., Rottmann, M., and Kertscher, U. (1994). The enzymatic degradation of bradykinin in semen of various species. Andrologia 26, 295-301.
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Siems, W.E., Heder, G., Böttger, A., Winkler, A., Zipper, J., and Mueller-Esterl, W. (1994). Influence of bradykinin and peptidase inhibitors on the motility of mammalian spermatozoa. Can. J. Pharmacol. 72, 203.
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Böttger, A., Kertscher, U., Steinmann, C., Baeger, U., Siems, W.E., and Heder, G. (1993). Degradation of bradykinin in semen of ram and boar. Biochem Pharmacol 45, 1983-8.
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Siems, W.E., Hilse, H., Heder, G., and Böttger, A. (1992). Influences of bradykinin on the motility of spermatozoa. Arch.Pharmacol. 346, 16.
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Heder, G., Böttger, A., Siems, W.E., Halatsch, W.R., and Steinmann, C. (1988). The determination of neutral metalloendopeptidase (enkephalinase A) in biological material. Pharmazie 43: 637-9.