Publications
2014
- Takaku, Y., Hwang, J.S., Wolf, A., Boettger, A., Shimizu, H., David, C.N. and Gojobori,T. (2014). Innexin gap junctions in nerve cells coordinate spontaneous contractile behavior in Hydra polyps. Scientific Reports 4 : 3573 | DOI: 10.1038/srep03573
2012
-
David, C.N. (2012). Interstitial stem cells in Hydra: multipotency and decision-making. Int J Dev Biol 56: 489-497.
-
Boettger, A., Doxey, A.C., Hess, M.W., Pfaller, K., Salvenmoser, W., Deutzmann, R., Geissner, A., Pauly, B., Altstaetter, J., Muender, S., Heim, A., Gabius, H-J., McConkey, B.J., and David, C.N. (2012). Horizontal Gene Transfer Contributed to the Evolution of Extracellular Surface Structures: The Freshwater Polyp Hydra Is Covered by a Complex Fibrous Cuticle Containing Glycosaminoglycans and Proteins of the PPOD and SWT (Sweet Tooth) Families. PLoS ONE 7(12): e52278. doi:10.1371/journal.pone.0052278.
2011
-
Aufschnaiter, R., Zamir, E.A., Little, C.D., Ozbek, S., Munde,r S., David, C.N., Li, L., Sarras, M.P., Zhang, X. (2011). In vivo imaging of basement membrane movement: ECM patterning shapes Hydra polyps. J Cell Sci 124: 4027-4038.
-
Steele, R.E., David, C.N., and Technau, U. (2011). A genomic view of 500 million years of cnidarian evolution. Trends in Genetics 27: 7-13.
2010
-
Hwang, J.S., Takaku, Y., Momose, T., Adamczyk, P., Özbek, S., Ikeo, K., Khalturin, K., Hemmrich, G., Bosch, T.C.G., Holstein, T.W., David, C.N., and Gojobori, T. (2010). Nematogalectin, a nematocyst protein with GlyXY and galectin domains, demonstrates nematocyte-specific alternative splicing in Hydra. Proc Natl Acad Sci USA 107: 18539-18544.
-
Chapman, J.A., Kirkness, F., Simakov, O., .... Bode, H.R., David, C.N., Rokhsa,r D.S., and Steele, R.E. (2010). The dynamic genome of Hydra. Nature 464: 592-596.
-
Lasi, M., David, C.N., and Böttge,r A. (2010). Apoptosis in pre-Bilaterians: Hydra as a model. Apoptosis 15: 269-278.
-
Lasi, M., Pauly, B., Schmidt, N., Cikala, M., Stiening, B., Käsbauer, T., Zenner, G., Popp, T., Wagner, A., Knapp, R.T., Huber, A.H., Grunert, M., Söding, J., Cavid, C.N., and Böttger, A. (2010). The molecular cell death machinery in the simple cnidarian Hydra includes an expanded caspase family and pro- and anti-apoptotic Bcl-2 proteins. Cell Research 20: 812-825.
2009
-
Rolland, S.G., Lu, Y., David, C.N., and Conradt, B. (2009). The BCL-2–like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2– and EAT-3/Opa1–dependent mitochondrial fusion. J Cell Biol 186: 525-40.
-
Takahashi, T., Koizumi, O., Hayakawa, E., Minobe, S., Suetsugu, R., Kobayakawa, Y., Bosch, T.C.G., David, C.N., and Fujisawa, T. (2009). Further characterization of the PW peptide family that inhibits neuron differentiation in Hydra. Dev Genes Evol 219: 119-29.
2008
-
David, C.N., Özbek, S., Adamczyk, P., Meier, S., Pauly, B., Chapman, J., Hwang, J.S., Gojobori, T., and Holstein, T.W. (2008). Evolution of complex structures: minicollagens shape the cnidarian nematocyst. Trends in Genetics 24: 431-438.
-
Hwang, J.S., Takaku, Y., Chapman, J., Ikeo, K., David, C.N., and Gojobori, T. (2008). Cilium evolution: identification of a novel protein, nematocilin, in the mechanosensory cilium of Hydra nematocytes. Molecular Biology and Evolution 25: 2009-2017.
2007
-
Hwang, J.S., Ohyanagi, H., Hayakawa, S., Osato, N., Nishimiya-Fujisawa, C., David, C.N., Fujisawa, T., and Gojobori, T (2007). The evolutionary emergence of cell type specific genes inferred from gene expression analysis of Hydra. Proc Natl Acad Sci USA 104: 14735-14740.
-
Pauly, B., Lasi, M., Mackintosch, C., Morrice, N., Imhof, A., Regua, J., Rudd, S., David, C.N., and Böttger, A. (2007). Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organization and Ca2+ signaling. BMC Cell Biol 8: 31.
-
Käsbauer, T., Towb, P., Alexandrova, O., David, C.N., DallÁrmi, E., Staudigl, A., Stiening, B., and Böttger, A. (2007). The notch signaling pathway in the cnidarian Hydra. Dev. Biol. 303: 376-390.
-
Meier, S., Jensen, P.R., David, C.N., Chapman, J., Holstein, T.W., Grzesiek, S., and Özbek, S. (2007). Continuous molecular evolution of protein-domain structures by single amino acid changes. Current Biology 17: 173-178.
2006
-
Böttger, A., Strasser, D., Alexandrova, O., Levin, A., Fischer, S., Lasi, M., Rudd, S., and David, C.N. (2006). Genetic screen for signal peptides in Hydra reveals novel secreted proteins and evidence for non-classical protein secretion. Eur J Cell Biology 85:1107-1117.
2005
-
Alexandrova, O., Schade, M., Böttger, A., and David, C.N. (2005). Oogenesis in Hydra: nurse cells transfer cytoplasm directly to growing oocyte. Dev. Biol. 281: 91-101.
-
David, C.N., Schmidt, N., Schade, M., Pauly, B., Alexandrova, O., and Böttger, A. (2005). Hydra and the evolution of Apoptosis. Integr. Comp. Biol. 45: 631-638.
2004
-
Alexopolous, H., Böttger, A., Fischer, S., Levin, A., Wolf, A., Fujisawa, T., Hayakawa, S., Gojobori, T., Davies, J.A., David, C.N., and Bacon, J.P. (2004). Evolution of gap junctions: the missing link. Current Biology 14: R1-R2.
-
Cikala, M., Alexandrova, O., David, C.N., Pröschel, M., Stiening, B., Cramer, P., and Böttger, A, (2004). The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity. BMC Cell Biology 5: 26.
-
Katsukura, Y., Ando, H., David, C.N., Grimmelikhuijzen, C.J.P., and Sugiyama, T. (2004). Control of planula migration by LWamide and RFamide neuropeptides in Hydractinia echinata. J Exp Biol 207: 1803-1810.
2003
-
Katsukura, Y., David, C.N., Grimmelikhuijzen, C.J.P., and Sugiyama, T. (2003). Inhibition of metamorphosis by RFamide neuropeptides in planula larvae of Hydractinia echinata. Dev Genes Evol 213: 579-586.
-
Alexandrova, O., Solovei, I., Cremer, T., and David, C.N. (2003). Replication labeling patterns and chromosome territories typical of mammalian nuclei are conserved in the early metazoan Hydra. Chromosoma 112: 190-200.
-
Pauly, B., Stiening, B., Schade, M., Alexandrova, O., Zoubeck, R., David, C.N., and Böttger, A. (2003). Two isoforms of 14-3-3 protein in Hydra: molecular cloning and protein distribution patterns. Exp. Cell Res. 285: 15-26.
-
Böttger, A. and David, C.N. (2003). Evolution of cell death: caspase mediated mechanisms in early Metazoans; non-caspase mechanisms in single celled eukaryotes. In Genetics of Apoptosis (ed Stefan Grimm). Pp 145-154.
2002
-
Herold, M., Cikala, M., MacWilliams, H., David, C.N., and Böttger, A. (2002). Cloning and Characterization of PKB and PRK homologs from Hydra and the evolution of the protein kinase family. Dev Genes Evol. 212: 513-519
-
Böttger, A., Alexandrova, O., Cikala, M., Schade, M., Herold, M., and David C.N. (2002). GFP Expression in Hydra: lession from the particle gun. Dev. Genes Evol. 212: 302.
-
Szczepanek, S., Cikala, M. and David, C.N. (2002). Poly-gamma-glutamate synthesis during formation of nematocyst capsules in Hydra. J Cell Science 115: 745-51.
2001
-
Engel, U., Pertz, O., Fauser, C., Engel, J., David, C.N., and Holstein, T.W. (2001). A switch in S-S linkage in minicollagen assembly during capsule formation of Hydra nematocytes. EMBO Journal 20: 3063.
1999
-
Cikala, M., Wilm, B., Hobmayer, E., Böttger, A., and David, C.N. (1999). Identification of caspases and apoptosis in the simple metazoan Hydra. Current Biology 9: 959.
1998
-
Koch, A., Holstein, T.W., Mala, C., Kurz, E., Engel, J., and David, C.N. (1998). Spinalin, a new gylcine and histidine rich protein in spines of Hydra nematocysts. J Cell Science 111: 1545.
1997
-
Hager, G. and David, C.N. (1997). Pattern of differentiated nerve cells in hydra is determined by precursor migration. Development 124: 569.
-
Takahashi, T., Muneoka, Y., Lohmann, J., Lopez der Haro, M., Bosch, T.C.G., David, C.N., Bode, H.R., Koizumi, O., Shimizu, H., Hatta, M., Fujisawa, T., and Sugiyama, T. (1997). Systematic isolation of peptide signaling molecules from hydra. Proc Natl Acad Sci USA 94: 1241.
-
Hobmayer, E., Holstein, T.W., and David, C.N. (1997). Stimulation of tentacle and bud formation by the neuropeptide head activator in Hydra. Dev Biol 183: 1-8.
1994
-
Holstein, T.W., Benoit, M., von Herder, G., Wanner, G., David, C.N., and Gaub, H. (1994). Fibrous minicollagens in Hydra nematocysts. Science 265: 402.
-
Weinziger, R., Salgado, L.M., David, C.N., and Bosch, T.C.G. (1994). Ks1, an epithelial cell specific gene, responds to early signals of head formation in Hydra. Development 120: 2511.
-
Lopez de Haro, M.S., Salgado, L.M., David, C.N., and Bosch, T.C.G. (1994). Hydra tropomyosin (TROP1) is expressed in head specific epithelial cells and is a major component of the cytoskeletal structure that anchors nematocytes. J Cell Science 107: 1403.
-
David, C.N. and Hager, G. (1994). Formation of a primitive nervous system: nerve cell differentiation in the polyp hydra. In Perspectives on Developmental Neurobiology 2: 135.
1992
-
Holstein, T., Mala, C., Kurz, E., Bauer, K., Greber, M.J., and David, C.N. (1992). The primitive metazoan Hydra expresses antistasin, a serine protease inhibitor of vertebrate coagulation: cDNA cloning, cellular localisation and developmental regulation. FEBS Letters 309: 288.
-
Greber, M.J., David, C.N., and Holstein, T. (1992). A quantitative method for separation of living hydra cells. Roux Archives Dev Biol 201: 296.
1991
-
Holstein, T., Hobmayer, B. and David, C.N. (1991). The epithelial growth pattern in hydra. Dev Biol 148: 602.
-
Kurz, E., Holstein, T., Petri, B., Engel, J., and David, C.N. (1991). Minicollagens in Hydra nematocytes. J Cell Biol 115: 1159.
-
Bosch, T.C.G., Rollbühler, R., Scheider, B., and David, C.N. (1991). Role of the cellular environment in interstitial stem cell proliferation in hydra. Roux Archives Dev Biol 200: 269.
-
David, C.N., Fujisawa, T., and Bosch, T.C.G. (1991). Interstitial stem cell proliferation in hydra: evidence for strain specific regulatory signals. Dev Biol 148: 501.
-
Bosch, T.C.G., and David, C.N. (1991). Decision-making in interstitial stem cells of hydra. In vivo 5: 521.
1990
-
Hobmayer, E., Holstein, T., and David, C.N. (1990). Tentacle morphogenesis in hydra. I. The role of head activator. Development 109: 887.
-
Hobmayer, E., Holstein, T., and David, C.N. (1990). Tentacle morphogenesis in Hydra. II. Formation of a complex between a sensory nerve cell and a battery cell. Development 109: 897.
-
Fujisawa, T., David, C.N., and Bosch, T.C.G. (1990). Transplantation stimulates interstitial cell migration in hydra. Dev Biol 138: 509.
-
Bosch, T.C.G., and David, C.N (1990). Cloned interstitial stem cells grow as contiguous patches in hydra. Dev Biol 138: 513.
-
Holstein, T. and David, C.N. (1990). Cell cycle length, cell size and proliferation rate in hydra stem cells. Dev Biol 142: 392.
-
Holstein, T. and David, C.N. (1990). Putative intermediates in the nerve cell differentiation pathway in hydra have properties of multipotent stem cells. Dev Biol 142: 401.
1989
-
Hobmayer, E. and David, C.N. (1989). Differentiation of a nerve cell - battery cell complex in hydra. In The Evolution of the Nervous System, NATO Advance Workshop (Peter Anderson, ed).
1987
-
Bosch, T.C.G. and David, C.N. (1987). Stem cells of Hydra magnipapillata can differentiate into somatic cells and germline cells. Dev Biol 121: 182-191.
-
David, C.N., Bosch, T.C.G., Hobmayer, E., Holstein, T., and Schmidt, T. (1987). Interstitial stem cells in Hydra. In Genetic Regulation of Development (ed. WF Loomis) pp 389-408. Alan Liss Publishers, New York.
1986
-
Holstein, T., Schaller, C., and David, C.N. (1986). Nerve cell differentiation in Hydra requires two signals. Dev Biol 115: 9.
-
Holstein, T. and David, C.N. (1986). The properties of nerve cell precursors in Hydra. Dev Biol 115: 18.
-
Bosch, T.C.G. and David, C.N. (1986). Male and female stem cells and sex reversal in Hydra polyps. Proc Natl Acad Sci USA 83: 9478.
-
Bosch, T.C.G. and David, C.N. (1986). Immunocompetence in Hydra: epithelial cells respond to self-nonself and react against it. J exp Zool 238: 225.
-
Schmidt, T. and David, C.N. (1986). Gland cells in Hydra: cell cycle kinetics and development. J Cell Science 85: 197.
-
Weijer, C.J., Sternfeld, J., and David, C.N. (1986). Vital staining methods used in the analysis of cell sorting in Dictyostelium. Methods in Cell Biology (ed J Spudich) Academic Press.
1985
-
Munck, A. and David, C.N. (1985). Cell proliferation and differentiation kinetics during spermatogenesis in Hydra carnea. Roux Archives Dev Biol 194: 247.
-
David, C.N. and Holstein, T. (1985). The neuropeptide head activator causes nerve cell commitment in hydra. Archives Sci Genf 38: 461.
1984
-
Bosch, T.C.G. and David, C.N. (1984). Growth regulation in hydra: relationship between epithelial cell cycle length and growth rate. Dev Biol 104: 161.
-
Fujisawa, T. and David, C.N. (1984). Loss of differentiating nematocytes induced by regeneration and wound healing in hydra. J Cell Science 68: 243.
-
MacWilliams, H.K. and David, C.N. (1984). Pattern formation in Dictyostelium. In Microbial Development (Shapiro and Losick ed ). pp 255-274.
-
Weijer, C.J., Duschl, G., David, C.N. (1984). A revision of the Dictyostelium cell cycle. J Cell Science 70: 111.
-
Weijer, C.J, Duschl, G., David, C.N. (1984). Dependence of cell type proportioning and sorting on cell cycle phase in Dictyostelium. J Cell Science 70: 133.
1983
-
David, C.N. (1983). Cloning interstitial stem cells. In Methods in Hydra Research (Lenhoff H ed). Plenum Press.
-
David, C.N. (1983). The maceration technique for identification of hydra cells. In Methods in Hydra Research (Lenhoff H ed). Plenum Press.
-
David, C.N. (1983). Nitrogen mustard treatment of hydra. In Methods in Hydra Research (Lenhoff H ed). Plenum Press.
-
David, C.N. (1983). Cell cycle analysis of hydra. In Methods in Hydra Research (Lenhoff H ed). Plenum Press.
-
David, C.N. (1983). Microinjection techniques for labeling hydra. In Methods in Hydra Research (Lenhoff H ed). Plenum Press.
-
David, C.N. (1983). Stem cell proliferation and differentiation in hydra. In Identification and Characterization of stem cell populations (CS Potten ed) Churchill-Livingstone Publishers.
1982
-
Fujisawa, T. and David, C.N. (1982). Commitment during stenotele differentiation in hydra is localized near the S/G2 boundary in the terminal cell cycle. Dev Biol. 93: 226.
-
Sternfeld, J. and David, C.N. (1982). Fate and regulation of anterior-like cells in Dictyostelium slugs. Dev Biol 93:111.
1981
-
Venugopal, G. and David, C.N. (1981). Spatial pattern of nerve cell differentiation in hydra is due to a pattern of nerve cell commitment. Dev Biol 83: 366.
-
Venugopal, G. and David, C.N. (1981). Nerve cell commitment in hydra. I Role of morphogenetic signals. Dev Biol 83: 353.
-
Venugopal, G. and David, C.N. (1981). Nerve cell commitment in hydra: II. Localization of commitment in S phase. Dev Biol. 83: 361.
-
Fujisawa, T. and David, C.N. (1981). Commitment during nematocyte differentiation in Hydra. J Cell Science 48: 207.
-
Sternfeld, J. and David, C.N. (1981). Oxygen gradients cause pattern orientation in Dictyostelium cell clumps. J Cell Science 50: 9.
-
Sternfeld, J. and David, C.N. (1981). Cell sorting during pattern formation in Dictyostelium. Differentiation 20: 10.
1980
-
David, C.N. and Plotnick, I. (1980). Distribution of interstitial stem cells in hydra. Dev Biol 76: 175.
-
David, C.N. (1980). Control of stem cell proliferation in Hydra attenuata. In Developmental and Cellular Biology of Coelenterates (Tardent and Tardent eds) Elsner-North Holland Press.
1979
-
Sproull, R. and David, C.N. (1979). Stem cell growth and differentiation in hydra I. Regulation of the self-renewal probability in multiclone aggregates. J Cell Science 38: 155.
-
Sproull, R. and David, C.N. (1979). Stem cell growth and differentiation in hydra. II. Regulation of nerve and nematocyte differentition in multiclone aggregates. J Cell Science 38: 171.
-
Sternfeld, J. and David, C.N. (1979). Ammonia plus another factor are necessary for differentiation in submerged clumps of Dictyostelium. J Cell Science 38: 181.
1978
-
Bode, H. and David, C.N. (1978). Interstitial stem cells in Hydra. In Progress in Biophysics and Molecular Biology (Butler and Nobel eds) 33: 189.
-
David, C.N. and MacWilliams, H. (1978). Regulation of the self-renewal probability in hydra stem cell clones. Proc Natl Acad Sci USA 75: 886.
1977
-
David, C.N. and Murphy, S. (1977). Characterisation of interstitial stem cells in Hydra by cloning. Dev Biol 58: 47.
1975
-
David, C.N. (1975). Stem cell differentiation in Hydra. In Microbiology 1975 (Shapiro and Dworkin, eds) American Society for Microbiology.
1974
-
David, C.N. and Challoner, D. (1974). Distribution of interstitial cells and differentiating nematocytes in nests in Hydra. Am Zool 14: 537.
-
Campbell, R.D. and David, C.N. (1974). Cell cycle kinetics and development in Hydra. II. Interstitial cells. J Cell Science 16: 349.
-
David, C.N. and Gierer, A. (1974). Cell cycle kinetics and development in Hydra. III Nerve and nematocyte differentiation. J Cell Science 16: 359.
-
David, C.N. (1974). Ferritin and iron metabolism in Phycomyces. in Microbial Iron Metabolism (ed JB Neilands) Academic Press.
1973
-
David, C.N. (1973). A quantitative method for maceration of hydra tissue. Roux Archives Dev. Biol. 171: 259.
-
Bode, H., Berking, S., David, C.N., Gierer, A., Schaller, H., and Trenkner, E. (1973). Quantitative analysis of cell types during growth and morphogenesis in hydra. Roux Archives Dev Biol 171: 269.
1972
-
David, C.N., Campbell, R. (1972). Cell cycle kinetics and development in Hydra attenuata I. Epithelial cells. J Cell Science 11: 557.
-
Gierer, A., Berking, S., Bode, H., David, C.N., Flick, K., Hansmann, G., Schaller, C., Trenkner, E. (1972). Regeneration of Hydra from reaggregated cells. Nature New Biol. 239: 98.
1971
-
David, C.N. and Easterbrook, K. (1971). Ferritin in the fungus Phycomyces. J Cell Biol. 48: 15.
1970
-
Camereon, R.E., King, J., and David, C.N. (1970). Soil microbial ecology in Wheeler Valey, Antarctica. Soil Sci 109: 119.
-
Cameron, R.E., King, J., and David, C.N. (1970). Microbiology, ecology and microclimatology of soil sites in Dry Valleys of southern Victoria Land, Antarctica. In Antarctic Ecology (ed MW Holdgate). Academic Press.
1969
-
Bergman, K., Burke, P.V., Cerda-Olmeda, E., David, C.N., Delbruck, M. et al (1969). Phycomyces. Bact Rev 33: 99.
1968
-
Cameron, R.E., King J., and David, C.N. (1968). Soil microbial and ecological studies in southern Victoria Land. Antarctic J USA 3: 121.
-
Cameron, R.E., David, C.N., and King, J. (1968). Soil toxicity in Antarctic Dry Valleys. Antarctic J USA 3: 164.
-
David, C.N. (1968). Ferritin in the fungus Phycomyces. PhD Thesis. California Institute of Technology, Pasadena.
1964
-
David, C.N. (1964). UV inactivation and thymine dimerization in bacteriophage X174. Z Vererbungslehre 95: 318.
1962
-
Clarke, G.L., Conover, R.J., David, C.N., and Nicol, J.A.C. (1962). Comparative studies of luminescence in copepods and other pelagic marine animals. J marine biol Assn. UK 42: 541.
1961
-
David, C.N. and Conover, R.J. (1961). Preliminary investigation on the physiology and ecology of luminescence in the copepod Metridia lucens. Biol Bull 121: 92.